Pharmacology
Phase 2 — Target Identification & Compound Profiling
2.6 ADMET Prediction and Compound Profiling
2.6.4 Excretion

2.6.4 Excretion

Renal clearance, biliary excretion, and P-glycoprotein-mediated efflux (commonly assessed via the Caco-2 basolateral-to-apical/apical-to-basolateral, or...

PharmacologyPhase 2 — Target Identification & Compound Profiling2.6 ADMET Prediction and Compound Profiling1 min readUpdated 2026-07-13

Renal clearance, biliary excretion, and P-glycoprotein-mediated efflux (commonly assessed via the Caco-2 basolateral-to-apical/apical-to-basolateral, or B-A/A-B, permeability ratio) together determine the elimination pathway and half-life of a compound.

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1.4.1 Neuropharmacology1.4.2 Cardiovascular Pharmacology1.4.3 Chemotherapy (Anticancer and Anti-infective Pharmacology)1.4.4 Endocrine Pharmacology
2.6.3 Metabolism2.6.5 Toxicity (In-Silico)