2.3.6 Kinases

Kinases catalyse phosphorylation-based signal transduction and represent a major class of contemporary anticancer...

Kinases catalyse phosphorylation-based signal transduction and represent a major class of contemporary anticancer targets. Tyrosine kinase inhibitors such as imatinib and gefitinib, and serine/threonine kinase inhibitors, act by competing at the ATP-binding site or by allosteric inhibition of catalytic activity.