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Preparative HPLC

Preparative high-performance liquid chromatography scales the analytical HPLC technique described in Phase 3 to isolate milligram-to-gram quantities of...

Pharmaceutical Chemistry / Phase 2 – Organic Synthesis & Reaction Optimization

ICH Q2(R2) Analytical Method Validation

Introduction and Regulatory Purpose ICH Q2(R2), the internationally harmonised guideline on the validation of analytical procedures, establishes the formal...

Pharmaceutical Chemistry / Phase 4 – Purity Assessment & Analytical Validation

Principles of Pharmaceutical Stability

Chemical and Physical Degradation Pathways Pharmaceutical degradation may proceed through several chemical pathways, including hydrolysis of esters, amides,...

Pharmaceutical Quality Assurance / Stability-Indicating Methods and Stability Studies

Pharmacokinetic Data Analysis and Reporting

Non-Compartmental Analysis and Key Parameters Following generation of validated concentration-time data, non-compartmental analysis is typically performed...

Pharmaceutical Quality Assurance / Bioanalytical Method Development

Rational Drug Design

Rational drug design is the hypothesis-driven approach to compound design in which chemical structures are proposed on the basis of a defined understanding...

Pharmaceutical Chemistry / Phase 1 – Drug Design & Molecular Docking

Learning Objectives

Explain why standardisation is scientifically necessary for herbal, as distinct from synthetic, drugs.Describe the pharmacognostic quality parameters...

Phytopharmacy & Phytomedicine / Phase 5 — Standardization & Quality Control

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