2.6.1 Absorption

Oral absorption is estimated from calculated logP (an ideal range of approximately 1–3), pKa, aqueous solubility, and Caco-2 cell monolayer permeability,...

Oral absorption is estimated from calculated logP (an ideal range of approximately 1–3), pKa, aqueous solubility, and Caco-2 cell monolayer permeability, with a permeability coefficient above roughly 1 × 10⁻⁶ cm/s generally considered indicative of good intestinal absorption. MDCK (Madin–Darby Canine Kidney) cell monolayers serve as a complementary permeability model.