2.3.3 Enzymes

Enzymes are catalytic proteins that can be inhibited to block a specific biochemical...

Enzymes are catalytic proteins that can be inhibited to block a specific biochemical pathway. Cyclooxygenase (COX) inhibition underlies NSAID action, angiotensin-converting enzyme (ACE) inhibition underlies antihypertensive therapy with captopril-class drugs, HMG-CoA reductase inhibition underlies statin therapy, and kinase inhibition (for example imatinib) underlies much of modern targeted oncology. Carbonic anhydrase is a further classical enzymatic target.